TDP-43 and Neurodegeneration: From Bench to Bedside

By Vijay Kumar, Manoj Kumar Jaiswal Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Product Details Publisher ‏ : ‎ Academic Press; 1st edition (November 19, 2021) Language ‏ : ‎ English Paperback ‏ : ‎ 270 pages ISBN-10 ‏ : ‎ 0128200669 ISBN-13 ‏ : ‎ 978-0128200667 ISBN-13 ‏ : ‎ 9780128200667 eText ISBN: 9780128204405