Oncocytic (Hürthle Cell) Thyroid Lesions: From Diagnosis to Treatment

by Mahmoud Sakr This book provides a comprehensive overview of oncocytic (Hürthle cell) lesions, whether neoplastic or non-neoplastic, with a view to clarifying some uncertainties and helping clinicians reach an accurate diagnosis and choose the best therapeutic options. Many recent studies have highlighted important facts relevant to oncocytic (Hürthle cell) lesions and have proposed several clinical and non-clinical tools that may help in diagnosis and management. Recent molecular studies have shed light on the distinct oncogenic features of oncocytic/Hürthle cell carcinomas, suggesting that they represent a separate pathological entity from both oncocytic/Hürthle cell adenomas and follicular cell carcinomas. However, only a few facts are established, while challenges and debates still encompass most of the spectrum of oncocytic (Hürthle cell) lesions. The volume discusses a wide range of topics, including controversies in nomenclature, origin, and cytology/histology of oncocytic (Hürthle) cells, as well as controversies in oncocytic cell lesion pathogenesis, biological and clinical behavior, diagnosis, and management. Regarding oncocytic (Hürthle cell) neoplasms, this book discusses controversies in pathological classification, clinical presentation, diagnostic work-up, and therapeutic strategies. A special chapter addresses updates in genetic and molecular diagnostics of oncocytic (Hürthle cell) carcinoma. Finally, this book includes a chapter summarizing the recent international guidelines and recommendations related to oncocytic lesions, particularly carcinoma, thus aiding in decision-making and appropriate management. This book is meant for all specialists entrusted with the care of patients suffering from oncocytic thyroid lesions: head and neck surgeons, maxillofacial surgeons, endocrine surgeons, endocrinologists, oncologists, and otolaryngologists.