Exploration of Host Genetic Factors associated with Malaria

by Tabish Qidwai(Author) This book is aimed to cover the role of genetic polymorphisms in human genes related to RBC disorders, metabolic enzymes, immune response, and cytoadherence in the susceptibility/resistance to malaria caused by Plasmodium falciparum. The chapters provide current information on the balancing trait and the significance of such traits in the malaria resistance. The book covers polymorphisms in the genes of the red blood cells-sickle cell anaemia; glucose-6-phosphate dehydrogenase deficiency and thalassemia that confer protection against malaria. In addition, the book explores selection of genetic variations in the human genome as genetic control mechanism against malaria in endemic regions. It also provides a comprehensive overview of the molecular epidemiology and natural selection of alleles in the genes which are associated with malaria, and presents description of the role of human genetic polymorphisms in malaria disease risk and disease outcome. Product Details Publisher:Springer; 1st ed. 2021 edition (March 9, 2021) Language:English Hardcover:183 pages ISBN-10:9813347600 ISBN-13:978-9813347601 ISBN-13:9789813347601 eText ISBN: 9789813347618 Item Weight:15.9 ounces Dimensions:6.1 x 9.25 inches