Developmental Epilepsy: From Clinical Medicine To Neurobiological Mechanisms

This text serves as a concise yet comprehensive resource on developmental epilepsy, bridging the gap between basic science, genetics, and clinical practice. It provides a thorough exploration of the mechanisms underlying various childhood epilepsies while addressing contemporary clinical challenges. By integrating insights from laboratory research, clinical observations, and translational studies, the book equips clinicians, researchers, and students with a deeper understanding of the causes, progression, and potential treatments of pediatric epilepsy.

Key Features:

• Focus on developmental epilepsy from both clinical and basic science perspectives
• Introductory chapter on brain development to contextualize seizure onset and epilepsy emergence
• Examination of the relationship between childhood epilepsy and developmental cognitive impairment
• Exploration of febrile seizures and their potential role in subsequent epilepsy development
• Insights into immunity, inflammation, and epileptogenesis in the developing brain
• Coverage of epilepsy arising from brain malformations, neuronal migration deficits, and genetic syndromes
• Discussion of the mTOR pathway in specific pediatric epilepsy syndromes and therapeutic implications, including drug repurposing
• Analysis of the effects of steroid and sex hormones on neurotransmitter function and epilepsy development
• Consideration of early-life stress on brain development, behavior, and seizure susceptibility
• Digestible chapter lengths providing concise, high-yield information for clinicians and researchers