Chemistry and Biology of O-GlcNAcylation

By Wen Yi O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future. Product Details Publisher ‏ : ‎ Springer; 2024th edition (October 14, 2024) Language ‏ : ‎ English Hardcover ‏ : ‎ 185 pages ISBN-10 ‏ : ‎ 9819748631 ISBN-13 ‏ : ‎ 978-9819748631