{"product_id":"a-guide-to-sample-size-for-animal-based-studies","title":"A Guide to Sample Size for Animal-based Studies","description":"\u003cp\u003eby Penny S. Reynolds (Author) A Guide to Sample Size for Animal-based Studies Understand a foundational area of experimental design with this innovative reference Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs − Replacement, Reduction and Refinement − the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. A Guide to Sample Size for Animal-based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to “rightsizing” animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. This book offers: Step-by-step guidance in diverse methods for approximating and refining sample size Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies Sample size approximation methods for different types of data − binary, continuous, ordinal, time to event − and different study types − description, comparison, nested designs, reference interval construction and dose-response studies Numerous worked examples, using real data from published papers, together with SAS and R code A Guide to Sample Size for Animal-based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers. Product Details Publisher: Wiley; August 29, 2023 Language: English ISBN: 9781119799979 ISBN: 9781119799993\u003c\/p\u003e","brand":"Scientific Research","offers":[{"title":"Default Title","offer_id":48973481410734,"sku":null,"price":27.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0765\/8179\/8062\/files\/9781119799979-9781119799993-9781119799986-9781119800002.jpg?v=1787999113","url":"https:\/\/ebooksmedical.com\/products\/a-guide-to-sample-size-for-animal-based-studies","provider":"Ebooks Medical","version":"1.0","type":"link"}