[Free] USMLE road map biochemistry PDF

CONTENTS51TLFEIDuqL._BO2,204,203,200_PIsitb-sticker-arrow-click,TopRight,35,-76_AA300_SH20_OU01_
Abbreviations x
Acknowledgments xi
1 Physiologic Chemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
I. Water 1
II. Electrolytes 1
III. Acids and Bases 2
IV. pH 2
V. Buffers 3
VI. Amphipathic Molecules 6
Clinical Problems 6
Answers 8
2 Protein Structure and Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
I. Amino Acids 9
II.Charge Characteristics of Amino Acids and Proteins 10
III. Protein Structure 11
IV. Collagen 13
V. The Oxygen Binding Proteins—-Myoglobin and Hemoglobin 15
VI. Antibodies 19
Clinical Problems 19
Answers 21
3 The Physiologic Roles of Enzymes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 23
I. Enzyme-Catalyzed Reactions 23
II. Enzyme Classification 25
III. Catalysis of Reactions by Enzymes at Physiologic Temperature 26
IV. Mechanisms of Enzyme Catalysis 27
V. Kinetics of Enzyme-Catalyzed Reactions 29
VI. Enzyme Inhibitors 30
VII. Coenzymes and Cofactors 32
VIII. Allosteric Regulation of Enzymes 33
Clinical Problems 34
Answers 36
4 Cell Membranes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
I. Overview of Membrane Structure and Function 37
II. Membrane Components: Lipids 37
III. Organization of the Lipid Bilayer 39
IV. Membrane Components: Proteins 42
V. Membrane Components: Carbohydrates 42
VI. Transmembrane Transport 44
Clinical Problems 48
Answers 50
v
For more information about this title, click here
5 Metabolic Interrelationships and Regulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52
I. Diet and Nutritional Needs 52
II. Regulation of Metabolic Pathways 54
III. Glucose Homeostasis 56
IV. Metabolism in the Fed State 58
V. Metabolism in the Fasting State 61
VI. Metabolism During Starvation 63
Clinical Problems 66
Answers 68
6 Carbohydrate Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70
I. Digestion and Absorption of Dietary Carbohydrates 70
II. Glycolysis 70
III. Regeneration of NAD
+
73
IV. Pentose Phosphate Pathway 76
V. Key Enzymes Regulating Rate-Limiting Steps of Glucose Metabolism 78
VI. Glycogen Metabolism 78
VII. Gluconeogenesis 82
VIII. Metabolism of Galactose and Fructose 85
Clinical Problems 87
Answers 88
7 The TCA Cycle and Oxidative Phosphorylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90
I. Overview of the Tricarboxylic Acid (TCA) Cycle 90
II. Biosynthesis of Acetyl CoA 90
III. Steps of the TCA Cycle 92
IV. Regulation of the TCA Cycle 94
V. Role of the TCA Cycle in Metabolic Reactions 94
VI. Synthesis of Oxaloacetate from Pyruvate 95
VII. The Electron Transport Chain 96
VIII. Energy Capture During Electron Transport 97
IX. Energy Yield of Oxidative Phosphorylation 97
X. Inhibitors of ATP Generation 97
Clinical Problems 99
Answers 101
8 Lipid Metabolism. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103
I. Digestion and Absorption of Dietary Fats 103
II. The Lipoproteins: Processing and Transport of Fats 104
III. Functions of Fatty Acids in Physiology 105
IV. Fatty Acid Synthesis 106
V. Fatty Acid Oxidation 109
VI. Metabolism of Ketone Bodies 113
VII. Cholesterol Metabolism 115
VIII. Uptake of Particles and Large Molecules by the Cell 117
Clinical Problems 118
Answers 120
9 Nitrogen Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122
I. Digestion of Dietary Proteins 122
II. Metabolism of Ammonia 123
III. The Urea Cycle 124
IV. Catabolism of Amino Acids 126
vi Contents
N
V. Biosynthesis of Amino Acids 129
VI. Porphyrin Metabolism 131
Clinical Problems 135
Answers 137
10 Nucleic Acid Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . 139
I. Structures and Functions of Nucleotides 139
II. Biosynthesis of Purines 139
III. Biosynthesis of Pyrimidines 142
IV. Degradation of Purine and Pyrimidine Nucleotides 146
V. Salvage Pathways 147
Clinical Problems 148
Answers 149
11 Nucleic Acid Structure and Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 151
I. Overview of Nucleic Acid Function 151
II. Structure of Chromosomal DNA 152
III. Replication 154
IV. Mutations and DNA Repair 158
V. RNA Structure 160
VI. Transcription 161
Clinical Problems 164
Answers 166
12 Gene Expression. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . 168
I. The Genetic Code 168
II. Steps in Translation 168
III. Post-translational Modification of Proteins 173
IV. Regulation of Gene Expression 176
V. Mutations 179
Clinical Problems 181
Answers 183
13 Human Genetics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
I. Overview of Mendelian Inheritance 185
II. Modes of Inheritance in Single-Gene Disorders 186
III. Major Concepts in Human Genetics 192
IV. Population Genetics: The Hardy-Weinberg Law 194
Clinical Problems 195
Answers 198
14 Cellular Signaling and Cancer Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .200
I. General Principles of Cellular Signaling 200
II. Signaling by G Protein-Coupled Receptors 201
III. Receptor Tyrosine Kinases 206
IV. The Nuclear Receptor Superfamily 207
V. Overview of Cancer Biology 210
VI. Oncogenes and Tumor Suppressor Genes 210
VII. Apoptosis 213
Clinical Problems 215
Answers 217
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 218

Only registered users can see links. Please click to REGISTER OR !!!
MEGA ACCOUNT IS SUSPEND, IF LINK DOWNLOAD EBOOKS DIE, PLEASE COMMENT FOR US, WE REUPLOAD THEM. THANK YOU VERY MUCH.

4 comments

  1. Hi, this book’s download link seems to be dead. Is it possible to get a reupoload? Thanks.

  2. The file you are trying to download is no longer available. The associated user account has been terminated due to multiple violations of our Terms of Service

Leave a Reply